The global “tableau” that Sec State Clinton inherits hasn’t changed much since this 2007 interview with Dr. Kissinger(on the challenges confronting Sec Rice, at the time.) But it still provides a nice summary–and some additional details on the US for policy-making machine:
Now, a number of things are going on simultaneously today that are not necessarily concurrent. In the North Atlantic, in Europe, the nation-state is disintegrating, but the new political unit, the European Union, has emerged here as a political non-factor. So in effect, Europe has no mechanisms for conducting strategic policy the way it used to be conducted by nation-states. Maybe that’s not possible for a transnational unit. That’s what we have to find out.In the relations between states, war is no longer possible. That’s a new factor. How do you conduct foreign policy when you can’t have war, and you have populations that are not willing to make any sacrifice for anything, including domestic changes? On the other hand, America is still a nation, and that greatly affects our relation with Europe.And we have Asia, which is more like Europe was in the 19th century, with the notion of equilibrium and balance of power, and so forth. Then you have the Middle East, which is like Europe was in the 17th century, torn by religious and sectarian conflicts. And on top of that, you have a new set of problems that have never existed before and can only be solved on a global basis—climate, energy, terror, for which there is no national mechanism really to deal with it.

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